i am considering to drop auto-server support for 1.0 (due the coming week, btw, with lots of improvements, fixes and features!).
Currently, if you install devpi, and then run "devpi install|upload|..." and are using the default http://localhost:3141 devpi instance, it will start and manage a background devpi-server process. The whole logic is hairy so i'd rather like to drop supporting it and require that you have a "devpi-server" running (for starters, just in another terminal, eventually in a --gendeploy'ed devpi-server or with your own init scripts).
As far as the quickstart is concerned, it adds another instruction like this::
devpi-server # run in a separate terminal
before you can proceed with "devpi ...".