How do you enable access to devpi at your company?

We're starting to deploy devpi at our company. We want to have a production instance of devpi that lives in our colo/the cloud, and then have developers run devpi locally and have a mirror of the production instance. Since, devpi will host our internally developed packages, we want some level of authentication/authorization in order to install packages from devpi (i.e. and not have devpi be completely public). Thus, I'm curious, how do most companies deploy devpi with authentication/authorization such that local developers can easily access the colo/cloud hosted instance of devpi when installing with pip? Do you use a VPN? Do you put devpi behind nginx? Do you use devpi-ldap? Something else completely? Thank you in advance for your response! Thank you, Ryan
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Ryan Rueth