I joined the list after this discussion:
and want to point out that even the most recent versions of Zope 2.x for example still recommend Python 2.4.
In other words, there are probably alot of web apps out there (eg think about sites on Plone CMS) potentially running Python 2.4. I run a dedicated Python 2.4 just for Plone for example (the buildout of which is based on virtualenv and setuptools anyway I guess).
Whether distutils2 would be used by these projects of course is another matter. Just pointing out Python 2.4 is absolutely not unimportant.