The PyGTK thing just happens to be where things are leading me personally. Its partly because VPython on Linux uses GTK and I would like to know it better for that reason. And its partly because ubuntu has helped re-ignite a long dormant interest in Linux as a desktop working environment, and I see GTK/Gnome as the Big Pond in that respect.
And you in particular will be happy to know that GTK2 *does* have a skins feature ;)
A closer look. wxPython *is* using GTK on Linux. So you can theme wxPython. Relief ;) I don't know what my issue here is really. Maybe when I get into it further I'll understand better why it is a good idea to have a layer between, rather than dealing directly with GTK. At one time, one answer may have been crossplatform issues. But it looks to me that GTK is itself becoming crossplatform. There is native OSX support http://gtk-osx.sourceforge.net/ And Windows http://www.gimp.org/~tml/gimp/win32/ And the .Net framework http://gtk-sharp.sourceforge.net/ On the other hand the wxPython does look juicy - PyCrust itself looks like its worth the price of admission. Its just seems so BIG, and beyond the scope of any immediate needs I might have, other than as a runtime for other folks cool stuff. But I am going to stop resisting, and explore it further. Art