In-Reply-To=< CACiMDdfjTECwYcHmvw2bjCTB_SFZaGMw4DXkUQb2npJ1Hvc+Qw@mail.gmail.com> I've already done something similar, but with x64 packages. To build a wheel file for lxml, and link to static dependencies that you've already downloaded or compiled yourself, you need to do this: 1) Modify the STATIC_INCLUDE_DIRS and STATIC_LIBRARY_DIRS variables in setup.py to point to your already downloaded/compiled dependencies. 2) Use the following command to build a wheel file for lxml: python setup.py bdist_wheel --static This should compile lxml and build a wheel file that links against the static dependencies. If you want more details, check out my blog post here: https://benbernardblog.com/how-to-build-lxml-and-get-its-debug-symbols-on-wi... Hope this helps! Benoit