I'm on Gentoo, seems it also patches the site.py accordingly:
https://gitweb.gentoo.org/repo/gentoo.git/tree/dev-
lang/python/python-2.7.16.ebuild#n106
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https://bugs.launchpad.net/bugs/1838866
Title:
Mailman 2.1: hardcoded site-packages dir prefix doesn't work on some
64 bit filesystem layouts
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