Check In any given year, ten percent of Americans suffer from a depressive disorder. This type of mental disorders includes major depression. The main symptoms of major depression are the following: • Being uninterested in things you used to enjoy • Feeling upset or empty • Crying without reason "no reason" • Feeling slowed down or feeling dissatisfied and unable to sit still • Weight gain or loss • Thoughts about suicide or death • Trouble thinking, recalling things or concentrating • Trouble making daily decisions • Problems sleeping, particularly in the early morning or waiting to sleep all the time • Feeling exhausted all the time • Feeling emotionally numb