[Mailman-Users] 2 Different Domains on Same Server - Is this Possible?

I already have an instance of mailman running with about 100 mailists.
My client is now asking if I could host another domain on the same server. So basically, I would require two web instances of mailman on the same box, because the clients are unique.

Is this possible, or will I have to procure and stage another mailman server?