Hi everybody, I hope this has not been discussed before, I couldn't find a solution elsewhere. I need to read some binary data, and I am using numpy.fromfile to do this. Since the files are huge, and would make me run out of memory, I need to read data skipping some records (I am reading data recorded at high frequency, so basically I want to read subsampling). At the moment, I came up with the code below, which is then compiled using cython. Despite the significant performance increase from the pure python version, the function is still much slower than numpy.fromfile, and only reads one kind of data (in this case uint32), otherwise I do not know how to define the array type in advance. I have basically no experience with cython nor c, so I am a bit stuck. How can I try to make this more efficient and possibly more generic? Thanks import numpy as np #For cython! cimport numpy as np from libc.stdint cimport uint32_t def cffskip32(fid, int count=1, int skip=0): cdef int k=0 cdef np.ndarray[uint32_t, ndim=1] data = np.zeros(count, dtype=np.uint32) if skip>=0: while k<count: try: data[k] = np.fromfile(fid, count=1, dtype=np.uint32) fid.seek(skip, 1) k +=1 except ValueError: data = data[:k] break return data