http://pastebin.com/UhnEurqb The above is a crude way to run pygtk from rpython (through CPython and talking on a pipe), but at least it partially works. Callbacks are limited to quoted lambdas, but some simple return types back to rpython is possible - i'm going to try that next. There is no support for dynamic attribute access, but most of pygtk involves function calls. Where attribute access is required, i guess extra proxy functions could be written. -brett