I am pleased to announce the release of xlwings v0.6.2: Finally you can use the VBA module with the "RunPython" command from Excel 2016 on Mac. Check the Release Notes for full details: http://docs.xlwings.org/whatsnew.html About xlwings: xlwings is a BSD-licensed python library that makes it easy to call python from Excel and vice versa: Interact with Excel from python using a syntax that is close to VBA yet pythonic. Replace your VBA macros/UDFs with python code and still pass around your workbooks as easily as before. xlwings fully supports NumPy arrays and Pandas DataFrames. It works with Microsoft Excel on Windows and Mac. http://xlwings.org