[Python-Dev] Mixed Python/C debugging

Having tried comp.lang.python with no response, I turn here... After at least ten years away from Python's run-time interpreter & byte code compiler, I'm getting set to familiarize myself with that again. This will, I think, entail debugging a mixed Python/C environment. I'm an Emacs user and am aware that GDB since 7.0 has support for debugging at the Python code level. Is Emacs+GDB my best bet? Are there any Python IDEs which support C-level breakpoints and debugging? Thanks, Skip