I think it's time to accept PEP 485. I've re-read it once more, and it looks like the text is in great shape. (My only recommendation would be to update the Abstract to state that we're specifically adding math.isclose().)
A wording question: "This implementation has a flag that lets the user select which relative tolerance test to apply -- this PEP does not suggest that that be retained, but rather than the weak test be selected." -- I think this was meant to say "... rather *that* the weak test be selected", right? (It would be nice if the sample implementation defaulted to the choice in the PEP.)
However, those are just minor edits, and I hereby approve the PEP. Thanks Chris and everyone else for the fruitful discussion (and thanks especially to Chris for eventually ending the bikeshedding and writing a PEP that explains each of the choices). Congrats!