How about not changing semantics and still making this optimization possible?
PyPy already has CALL_LIKELY_BUILTIN which checks whether builtins has been altered (by keeping a flag on the module dictionary) and if not, loads a specific builtin on top of value stack. From my current experience, I would make a bet that someone is altering pretty much every builtin for some dark reasons. One that comes to mind is to test something using external library which is not playing along too well.
That however only lets one avoid dictionary lookups, it doesn't give potential for other optimizations (which in my opinion are limited until we hit something dynamic like an instance, but let's ignore it). How about creating two copies of bytecode (that's not arbitrary number, just 2) and a way to go from more optimized to less optimized in case any of promises is invalidated? That gives an ability to save semantics, while allowing optimizations.
That said, I think CPython should stay as a simple VM and refrain from doing things that are much easier in the presence of a JIT (and give a lot more speedups), but who am I to judge.