Cython requires the end user to rewrite the module to be compiled in a pseudo-C language. With PysoniQ, there is no need to rewrite Python source code.
Nutika compiles to a C program, and there is more workflow instrusion. With Nutkia, you will need to install a C compiler and go through a manual compilation step that is not necessary with PysoniQ.
According to Nutika's website, Nutkia is "somewhat faster than CPython" and its current performance metric is 312% faster -- about 3 times faster. Our slowest metric is more than twice that, and our average unoptimized metric is more than 20 times faster than CPython. The average optimized metric is over 40 times faster.
Nutkia also mentions dependency issues with Windows. PysoniQ has no dependencies.
The metrics PysoniQ has achieved are largely due to Python-specific direct translation to assembly language without intermediate representation. Our goal was to give Python the fastest possible metrics with only minimal work for the end user. See the metrics at https://pysoniq.com/text_2.htm
Finally, with both of these, you need to do more than just point and click.
I will respond to Pythran in a moment.