There's a PR for this: "Immortal instances", by Eddie Elizondo (Facebook).

Github PR: https://github.com/python/cpython/pull/19474
Bug Report: https://bugs.python.org/issue40255

On Sat, Jun 13, 2020 at 3:48 AM Jonathan Fine <jfine2358@gmail.com> wrote:
Hi

Here's something that might make code run quicker. The basic idea is to not refcount some objects that are sure never to be deleted. On a multicore machine, this might significantly reduce the number of cache invalidations (and perhaps misses). I lack many of the skills needed to investigate this further.

Aside: This idea prompted by: Make `del x` an expression evaluating to `x`
https://mail.python.org/archives/list/python-ideas@python.org/message/WVQNATE7KYU5G64BQB5VEWALPYVS3QPV/

Consider
>>> tuple(id(n) - id(0) for n in range(10))
(0, 32, 64, 96, 128, 160, 192, 224, 256, 288)

Why? Small integers are stored at fixed locations, hence the arithmetic progression. Let's look at refcounts.
>>> import sys
>>> tuple(sys.getrefcount(n) for n in range(10))
(511, 837, 113, 54, 63, 35, 30, 20, 65, 17)

These refcounts are variable numbers. They can be changed (within limits).
>>> x = [0] * 100000
>>> tuple(sys.getrefcount(n) for n in range(10))
(100510, 837, 113, 54, 63, 35, 30, 20, 65, 17)

The same happens with None.
>>> sys.getrefcount(None)
8475
>>> x = [None] * 100000
>>> sys.getrefcount(None)
108475

For me the basic idea of the implementation would be to not refcount those objects, whose id lies in a certain range. As stated earlier, I suspect the main benefit will be on multicore machines being able to make better use of per-core caches.

If anyone is interested, I suggest starting with None, to get a rough estimate of the possible benefits (and cost of implementation).

As well as the python-ideas thread mentioned above, related to this is:
https://stackoverflow.com/questions/14139111/python-disable-reference-counting-for-some-objects

-- 
Jonathan
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