Hello, I just downloaded pythonnet-2.0-Beta0-clr4.0_140_py27.zip from http://sourceforge.net/projects/pythonnet/, and extract to c:\temp and ran nPython.exe, got below error. Current my test machine has Windows 2008 R2 SP1 with Python 2.7.3 (32bit). When looked the error, and googled it. someone says I need to copy python27.dll into c:\windows\system32. However, I can't find the file. Any idea? Thank you, Spark, C:\temp\pythonnet20>nPython.exe Unhandled Exception: System.DllNotFoundException: Unable to load DLL 'python27': The specified module could not be found . (Exception from HRESULT: 0x8007007E) at Python.Runtime.Runtime.Py_Initialize() at Python.Runtime.Runtime.Initialize() in D:\Users\Barton\Documents\Visual Studio 2010\Projects\PySharp\trunk\pythonn et\src\runtime\runtime.cs:line 78 at Python.Runtime.PythonConsole.Main(String[] args) in D:\Users\Barton\Documents\Visual Studio 2010\Projects\PySharp\ trunk\pythonnet\src\console\pythonconsole.cs:line 21