Hello, I am trying to use pytables with python.net. It is working great with python alone. What I am doing with python.net is: PythonEngine.Initialize(); PythonEngine.AcquireLock(); PyObject sys = PythonEngine.ImportModule("sys"); PyObject path = sys.GetAttr("path"); PyObject append = path.GetAttr("append"); PyObject[] a = new PyObject[1]; a[0] = new PyString("C:\\Python27\\Lib\\site-packages"); append.Invoke(a); PyObject pyTables = PythonEngine.ImportModule("tables"); if (pyTables == null) throw new PythonException(); The exception message is "ImportError : DLL load failed: Specified module not found." What could be the differences between python.net and python ? Is there any specific path to add ? Thanks a lot, Guillaume.