After recompiling the solution project of pythonent accordance with the procedure oleskii for the .NET framework 4, I'm having a problem with my code. Here are the first few lines where the crash occurs. import sys, clr sys.path.append ("G: / bin_EESPORt") clr.AddReference ("ASAM.HILAPI.Implementation") clr.AddReference ("ASAM.HILAPI.Interfaces") clr.AddReference ("dSPACE.HILAPI.EESPort") clr.AddReference ("dSPACE.HILAPI.EESPort.Interfaces") from System import * from System.IO import * from System.Threading import * from ASAM.HILAPI.dSPACE.EESPort import * #here crash PythonWin from ASAM.HILAPI.Implementation.EESPort.Error import * from ASAM.HILAPI.Interfaces.EESPort import * from ASAM.HILAPI.Interfaces.EESPort.Enum import * from ASAM.HILAPI.Interfaces.EESPort.ErrorFactory import * from ASAM.HILAPI.Interfaces.EESPort.ErrorObjects import * When in debug mode i execute the line below Pythonwin crash: from ASAM.HILAPI.dSPACE.EESPort import * #here crash PythonWin The PC system is windows 7 64-bit. The IDE used is PythonWin with Python 2.7.9 MSC v.1500 32-bit (Intel)] on win32. The Frameworks installed are: .NET Framework 4 Client Profile, .NET Framework 4 Extended, .NET Framework 4 Targeting Multi-Pack and Visual C # 2010 Express. Thank you in advance deposit for the help, I really need your help