More data: If I'm running Python from a Novell network share volume (that is, no local Python install) and try running a Python.NET script, I receive: Unhandled Exception: System.Security.Policy.PolicyException: Required permissions cannot be acquired. at CLRModule.initCLR() The script I'm running is simply a single line, "import CLR". Any tips from the .NET savvy programmers on the list? (Aside from: "Don't do that." ;) Additionally, I'm having trouble getting McMillan's installer to behave with the CLR imports. Is this something that may get resolved in the next beta? I've seen mention of switching to using the official import hooks in the TODO file in CVS. This sounds like something promising. TIA - It's really remarkable how well Python.NET works, and how simple it is to take C# code and convert it.