I tried to get PythonNet working on a Windows 7 machine with Python 2.6.6 installed. My test program is very simple: print "before import of clr" import clr print "done importing clr" When I run the above in Pythonwin, I get this error: ImportError: dynamic module does not define init function (initclr) I have these packages installed (names of the installers are listed here): python-2.6.6.msi (we must use 2.6 because of an application dependency --> Aveva Marine) pywin32-214.win32-py2.6.exe wxPython2.8-win32-ansi-2.8.9.2-py26.exe (and we must use wx......ansi-2.8.9.2..... because it's the only one that works in Aveva Marine 12.1.4) I retrieved this zip file from the PythonNet site (on sourceforge): pythonnet-2.0-alpha2-136-py26.zip And unzipped it and placed the contents of the UCS2 sub-directory (except for the python.exe) in the C:\python26 directory. (Including the clr.pyd and the Python.Runtime.dll). The simple test program I have above is also in the C:\python26 directory. And the PYTHONPATH environment variable contains C:\python26 (and a few other folders/directories). But I can't even get the first real statement - import clr - to work. I apologize if this ends up being a complete newbie question. If you have any ideas on what I'm missing, I would be extremely grateful. Johan Vinke GD-Nassco