I'm trying to use an embedded python interpreter from C# using pythonnet (the python3 compatible version found at https://github.com/renshawbay/pythonnet) My interpreter is located in D:\src\scratch\TestPythonNet\TestPythonNet\PythonRuntime and has the "Lib" and "Libs" folder from the python distribution. I've tested using the following code: //==================================================================== PythonEngine.PythonHome = @"D:\src\scratch\TestPythonNet\TestPythonNet\PythonRuntime"; PythonEngine.ProgramName = "PythonRuntime"; PythonEngine.Initialize(); using (Py.GIL()) { PythonEngine.RunSimpleString("print(1)"); } //==================================================================== But, it doesn't work. I get a "SystemError: PyEvalCodeEx: NULL globals". Everytime I try to get an object from python, the code fails. What am I doing wrong? ___________________________________________________________ This e-mail may contain confidential and/or privileged information. If you are not the intended recipient (or have received this e-mail in error) please notify the sender immediately and delete this e-mail. Any unauthorised copying, disclosure or distribution of the material in this e-mail is prohibited. Please refer to http://www.bnpparibas.co.uk/en/email-disclaimer/ for additional disclosures.