> Can you provide minimal reproducible code sample for both C# and Python?
Tried uploading a .zip file to GitHub but got error "We don't support that file type." Instead I put a dropbox file link in the issue.

 > What is the latest pythonnet version in which this works?
I only ever used pythonnet-2.0-alpha2-clr2.0_131_py27_UCS2 with Python 2.7.2, where it worked when controlling my .Net 3.5-based-based GUI app. I only updated my app to .NET 4.5.2 last week, which is the first time I tried CLR4-compatible PythonDotNet with Python 2.7.12.

 > Are you testing this from interactive python or ipython? There are some
 differences between the 2 options.
 - Command shell:  C:\Python27> python my.py

 > Please also open an issue on github.
 Done: ".NET Remoting support broken  #276" 

 > BTW, why have you not switched to WCF?
- Yeah, I know, Remoting is deprecated : (  Need to learn about WCF and see what kind of pain it will cause my long-established user base.
--------- Original Message --------- Subject: PythonDotNet Digest, Vol 147, Issue 18
From: pythondotnet-request@python.org
Date: 10/21/16 10:00 am
To: pythondotnet@python.org

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 Today's Topics:
 
 1. Support for CLR4 .NET Remoting (pythondotnet)
 2. Re: Support for CLR4 .NET Remoting (Denis Akhiyarov)
 
 
 ----------------------------------------------------------------------
 
 Message: 1
 Date: Thu, 20 Oct 2016 10:38:28 -0700
 From: "pythondotnet" <PythonDotNet@jnpcarole.com>
 To: pythondotnet@python.org
 Subject: [Python.NET] Support for CLR4 .NET Remoting
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 <20161020103828.3e63f68611bc0deecd5a6dd5fef89a2f.fe160eb814.mailapi@email09.godaddy.com>
 
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 Does pythonnet-2.1.0 support .NET Remoting? When I try to get an interface, python 2.7 crashes:
 
 Unhandled Exception: System.NullReferenceException: Object reference not set to an instance of an object.
 at Python.Runtime.ClassDerivedObject.ToPython(IPythonDerivedType obj)
 at Python.Runtime.Converter.ToPython(Object value, Type type)
 at Python.Runtime.MethodBinder.Invoke(IntPtr inst, IntPtr args, IntPtr kw, MethodBase info, MethodInfo[] methodinfo)
 at Python.Runtime.MethodObject.Invoke(IntPtr target, IntPtr args, IntPtr kw,MethodBase info)
 at Python.Runtime.MethodBinding.tp_call(IntPtr ob, IntPtr args, IntPtr kw)
 
 It's getting past these lines in my script:
 import clr
 clr.Addreference(my remoting DLL)
 from MyNamespace import *
 
 and choking on a static method in my app's remoting DLL call which returns the interface. Through logging, I can tell that the code in that static method call is successfully executing:
 (IMyInterface)Activator.GetObject(typeof(IMyInterface), url);
 and returning the object back to Python.
 
 This worked fine before when my app targeted .NET 3.5 and I used the CLR2 version of the Python for .NET package. Now my app targets .NET 4.5.2 so I:
 - Updated to Python 2.7.12
 - Updated the copy of my app's remoting DLL in c:\python27\dll
 - Removed the old Python for .NET package
 - Executed "pip install pythonnet", which gave me version 2.1.0.
 
 In C:\Python27\Lib\site-packages\ I see:
 clr.pyd
 Python.Runtime.dll v 2.0.0.2
 Python.Runtime.dll.config