Making progress, but still no success. I had my system admins re-install python with OpenSSL support. Looks like it works. I ran this command with no errors: >python -c "import ssl" But I still run into problems installing scikit. This was my install command > python setup.py install --prefix ~/SCIKIT Here are the last few lines of error messages: Processing dependencies for scikit-image==0.13.dev0 Searching for PyWavelets>=0.4.0 Reading https://pypi.python.org/simple/PyWavelets/ Download error on https://pypi.python.org/simple/PyWavelets/: [SSL: CERTIFICATE_VERIFY_FAILED] certificate verify failed (_ssl.c:581) -- Some packages may not be found! Couldn't find index page for 'PyWavelets' (maybe misspelled?) Scanning index of all packages (this may take a while) Reading https://pypi.python.org/simple/ Download error on https://pypi.python.org/simple/: [SSL: CERTIFICATE_VERIFY_FAILED] certificate verify failed (_ssl.c:581) -- Some packages may not be found! No local packages or download links found for PyWavelets>=0.4.0 error: Could not find suitable distribution for Requirement.parse('PyWavelets>=0.4.0') Does anyone know why this error occurs?