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I've got an extended version of the same query. I have installed gcc43 into /opt/local/bin from macports, and would like to use this gcc (and associated c++ and gfortran) to compile numpy/scipy/pytables/matplotlib. /opt/local/bin is at the start of my $PATH I understand I create ~/.pydistutils.cfg something like [config_fc] fcompiler=gfortran f77exec=gfortran-mp-4.3 f90exec=gfortran-mp-4.3 opt='-mtune=core2 -march=core2' [config] compiler=gcc cc=gcc-mp-4.3 But ... 1. how do i specify the gcc4.3 C++ compiler for matplotlib etc..? 2. how do i specify the C & C++ compiler options (like -mtune=core2, -march=core2) 2. do I need to add /opt/local/lib to my $LD_LIBRARY_PATH? Or is there a less drastic method? 3. Is there anything else I need? Apologies if I've missed the documentation. Regards, George Nurser.