My primary use of Twisted is as a web application server behind a reverse proxy. Personally, I would love to see some Amazon EC2 images with Twisted pre-installed. If there were some *paid* EC2 images availble right now that had an Nginx -> HAProxy -> Twisted app server (meaning Twisted pre-installed and ready to go) stack on it, I would definitely use it, simply because I'm going to have to set that up for myself pretty soon and I am neither a Linux nor an EC2 expert (I have so far only used existing vanilla AMIs for testing/development). I probably wouldn't pay much for it, maybe 1 or 2 cents per hour -- but that's still about $7.20 or $14.40 per month, per server, in perpetuity, for whoever set up that kind of AMI. If someone created some slick managament tools/UI, or if some organization wanted to provide professional support not only for Twisted but for the whole stack/virtual box, I'd pay considerably more. Aside from EC2, I don't have any interest, i.e., unless something changes I don't intend to ever run a web application on anything other than EC2 infrastructure ever again. The mere pre-installation of Twisted, even with ongoing professional support, on some other hosting provider's infrastructure wouldn't come close to tempting me to use that provider instead of EC2.