All,
So a long while back I volunteered to write a library to supply functions to replace pywin32 with a cffi backed implementation. Quite a bit of time has gone by since and about a year ago I closed the issue[0] where I was keeping track of the major functions, constants and structures I needed to implement to even consider replacing pywin32.
With that issue closed pywincffi may be in a position where the conversion can start. Sadly however I don't have the time myself to invest in the effort because I have a couple of other projects that have shifted my priorities. If there's someone here who does have the time to invest in the conversion I'm happy to support their efforts wherever I can.