Rather than write a bot specific to Twisted, why not just adapt the Twisted project to use a bot written by another project?

For example, the Zulip project has written zulipbot:

Docs for it are here:

and a presentation for it was given here:

A lot of the motivations for zulipbot are similar to what the Twisted project is facing:

such as giving non-committers the ability to add labels to issues or PR's.

zulipbot is actively used, and you can see it in action in their issues and PR's: https://github.com/zulip/zulip/issues?utf8=%E2%9C%93&q=is%3Aissue%20or%20is%3Apull

I've met some of the Zulip developers at Pybay.  They are really focused on improving developer experience and

onboarding of new developers.  Rather than maintain our own bot, the Twisted project would probably

get further along with zulipbot, and working with the zulip developers to fill in any missing gaps on that bot.

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Craig