1) Client TCP connects should be allowed to bind to a specific interface and port, e.g.: reactor.clientTCP('example.com', 80, p, bindAddress=('1.2.3.4', 999)) 2) UDP Ports's API should be formalized. Basically, the way UDP works from what I can see is that you create a Port, and for client connections you call the Port's createConnection(addr) method. Currently this returns a transport which is hooked up to a protocol, which is silly, it should return the protocol instance it contructs: port = reactor.listenUDP(8080, dnsFactory) clientProtocol = port.createConnection(("example.com", 53)) clientProtocol.query("....")