Hi All, I've posted a solution for wx - twisted integration. Based on Itamars suggestions of two threads. It's very easy to use. To call a twisted method from wx thread just do: netCall(someTwistedThing, myParam, kword1=x, kword2=1) It returns a deferred, that will be calledback and erredback safely in the wx thread. Same for calling gui stuff from a twisted thread. guiCall(someGuiThing, (p1, p2)) or even easier create an interlayer object: from twisted.protocols.basic import LineReceiver class Gui2Net(LineReceiver): ... def send(self, someData): self.transport.send(someData) send = makeNetSafe(send) In this example an instance of GuiNet can be used safely by the gui thread, it can send data, just like if it was a normal twisted call; it will return a deferred. "makeNetSafe" means make this net call safe to be called from the gui. There is also a "makeGuiSafe" call, but I haven't tested it. You can still use the wrapper object in your test cases if you dont have a gui. If no TwistedThread is instansiated netCall and makeNetSafe just pass through. Comments appreciated. Matthew Sherborne Sherborne International Ltd www.sherborneinternational.com