wrote: >>>> False > False >>>> blah = win32com.client.Dispatch('MSXML2.XMLHTTP') >>>> blah.open("POST", "12.5.81.49/crg_cbsil_vtest_52/crg.aspx", False) Does using an absolute URL for the url parameter help any? You've specified a relative URL (i.e. the folder 12.5.81.49 under the current location).