working with a large file

Rita rmorgan466 at
Mon Sep 12 12:34:52 CEST 2011

I have a large file, 18gb uncompressed, and I would like to know what is the
preferred method to read this file for random access. I have several
processes reading the file which different calculate arguments. My server
has 64gb of memory. Not sure what is the preferred way to do this?

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