Python GUI?

[CM]

> Tkinter -- Simple to use, but limited
> 
> PyQT -- You have a GUI designer, so I'm not going to count that

As others have pointed out, that's nonsensical.  If you don't like the GUI designer, just don't use it.  

> wxPython -- Very nice, very professional, approved by Python creator, but alas hard to get started with

Why is it hard to get started with?  Download the installer, install, and:

import wx
app = wx.App(False)  
frame = wx.Frame(None, -1, "Hello World")
frame.Show(True)
app.MainLoop()