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Hi, I know PythonNet has been specially designed to handle .NET/CLR compatibility but because of some other restrictions I want to use Python 2.3 to access a C# function. First of all is it possible? I am trying with following piece of code in C# (Server app) and python (client app). This is a class library in C# which is compiled and registered with following commands. csc /target:library Class1.cs regasm Try2005.dll /tlb:Try2005.tlb using System; using System.Runtime.InteropServices; namespace Try2005 { public class TestingCSBC { [Guid("1EB394AB-2D4A-4a52-9F22-E8ACAED4800F")] public interface IManagedInterface { int PrintHi(string name); } [Guid("2FD76301-489A-4dc3-BF6B-5DF6FCE96CB8")] public class InterfaceImplementation : IManagedInterface { public int PrintHi(string name) { Console.WriteLine("Hello, {0}!", name); //TestCSBCClass obj = new TESTDLLCOMLib.TestCSBCClass(); //obj.Displaymessage("In C# application!!"); return 33; } } } } Python code: import win32com.client try: serverObj = win32com.client.Dispatch("Try2005.TestingCSBC") except Exception,e: print "Dispatch error",e try: serverObj.PrintHi("But will it work on Tribon??") except Exception,e: print "Error while Calling C# function",e After running the above Py script I am getting following error output. Dispatch error (-2147024894, 'The system cannot find the file specified.', None, None) Error while Calling C# function name 'serverObj' is not defined Any pointers would be greatly appreciated. Thanks in advance.