[Mailman-Users] Blocking every "reply" messages

[Fabio Alves]

Hello,
I'm trying to setup a mailing list with about 85000 e-mail addresses.
We've sent one e-mail using mailman, but some hours later, we started to
receive tons of "RE:" messages, that should go to the reply-to e-mail. But
seems that some users dont do it.

Is there any way to block every reply messages? I only want to allow some
replies to be sent to mailing list.
Is that possible?